Is it true that buprenorphine is abusable only when combined with a CNS depressant?

The statement that buprenorphine is abusable only when combined with a central nervous system (CNS) depressant is not accurate, which is why "True" is not the correct answer. Buprenorphine, while it has a lower abuse potential compared to other opioids, can still be misused on its own. It is a partial agonist at the mu-opioid receptor, which means it can produce effects similar to other opioids, including euphoria. This capability contributes to its potential for abuse, especially in individuals with a history of substance use disorders.

Abuse can occur when individuals take buprenorphine in larger doses than prescribed or via non-prescribed methods, such as injecting it. While combining buprenorphine with CNS depressants like alcohol or benzodiazepines can amplify the sedative effects and increase the risk of harmful consequences, the potential for abuse exists independently. Thus, buprenorphine's nature allows for misuse without the need for it to be used alongside depressants.

Understanding the pharmacological profile of buprenorphine is vital in recognizing its abuse potential and implementing appropriate safeguards in medication-assisted treatment settings.